Premier League betting Odds have Arsenal as a -105 favorite and Fulham a +275 underdog, while a Draw is at +260.

Arsenal has some questions in goal. Wojciech Szczesny got the start against Aston Villa, but did little to impress. Four different goalies have started a game for Arsenal during the current EPL season. They need better play at the goalie position than what they have gotten the last two games. Offensively, Robin Van Persie is the main threat. His 17 goals are among the best in the EPL, and he gets good support from Samir Nasri.

Fulham has Mark Schwarzer in goal. He has provided consistency, though he has allowed a lot of goals. His 35 goals conceded will do little to inspire the Fulham fans. On the offensive side of the ball, Fulham features American star Clint Dempsey. He leads the team with 12 goals and his found his way in the EPL. The Fulham attack isn’t as strong as that of Arsenal, but they know how to score goals.

Arsenal grabbed a 2-1 victory against Fulham in the first meeting. They should have the edge in this match, but Arsenal has looked very vulnerable. A loss here would be a crushing way to end the EPL season. Expect Arsenal to attack hard in this game, but Fulham might be able to match them. This game could very well end in a draw, which would also be disappointing for Arsenal.

Manchester United always has the big target on its back, but that target is even larger this season. As the defending European champions, Man U finds itself in a dogfight for the Premier League title, trailing Chelsea 45 points to 43. With Arsenal just four points out of first, the championship doesn’t look to be decided any time soon.

The fourth member of England‘s Big Four hasn’t been as successful so far. With only 33 points, Liverpool is fighting just to make the 2010-11 Champions League, trailing Tottenham by four points for the fourth spot. Tottenham isn’t the only club they have to worry about; they need to leap over Aston Villa and Manchester City (both of whom have 35 points) to grab the league’s final Champions League spot.

Chelsea’s defense can be largely credited for getting them atop the table; their league-low 16 goals allowed has also given them the league’s best goal differential. Arsenal leads with 51 goals scored, led by Francesc Fabregas and Robin van Persie’s combined 16 points. With 21 goals allowed, though, the Gunners will need defensive improvement if they want to be champions.

The Premier League’s scoring title has been even more competitive, as Man U’s Wayne Rooney, Chelsea’s Didier Drogba and Tottenham’s Jermain Defoe currently have 14 points each, with Sunderland’s Darren Bent just a point behind them.